Programming the Myocardium: the Notch-Wnt Axis
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چکیده
منابع مشابه
Endocardial to Myocardial Notch-Wnt-Bmp Axis Regulates Early Heart Valve Development
Endocardial to mesenchymal transformation (EMT) is a fundamental cellular process required for heart valve formation. Notch, Wnt and Bmp pathways are known to regulate this process. To further address how these pathways coordinate in the process, we specifically disrupted Notch1 or Jagged1 in the endocardium of mouse embryonic hearts and showed that Jagged1-Notch1 signaling in the endocardium i...
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Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways.Methods: Co...
متن کاملCanonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.
RATIONALE Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease. OBJECTIVE To determine the role of canonical Wnt signaling in the myocardium during AVC development. METHODS AND RESULTS We used a novel allele of β-catenin that preserves β-catenin's...
متن کاملافزایش بیان مسیرهای پیام رسانی Notch و Wnt در سلوهای شبه بنیادی رده سلولی ملانومای متاستاتیک (A375)
زمینه وهدف: ملانومای متاستاتیک بدخیم‌ترین نوع سرطان پوست است؛ سختی‌های درمان ملانوما به وجود سلول‌های بنیادی سرطان در ملانوما نسبت داده شده‌اند. خصوصیات سلول‌های بنیادی سرطانی می‌تواند به‌وسیله به هم خوردن تنظیم مسیرهای پیام‌رسانی سلولی Notch و Wnt به دست بیاید. هدف ما از این مطالعه به دست آوردن سلول‌های بنیادی ملانوما از رده سلولی متاستاتیک A375 و سپس بررسی خودنوزایی و خصوصیا...
متن کاملNotch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros.
Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive. Here, we further the understanding of how Notch signalling patterns the early X. laevis pronephros anlagen, a function that might be conserved in mammalian ne...
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